#NEXUS 
begin data;
	dimensions ntax=7 nchar=4706;
	format datatype=protein interleave gap=-
		   symbols="12" equate="S={12}";
	options gapmode=newstate;

MATRIX

[Aldolase]

Arabidopsis       MS----AFVSKYEDELIKTAKYIATPGRGILAADESTETIGKRFAGINVENTESNRQAYR
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       MSRFQPYLTEAQENDLRRIAQAICAPGKGILAADESTATMGKRLQQIGVENNEENRRLYR
Caenorhabditis    MASYSQFLTKAQEDELRSIANAIVTPGKGILAADESTGSMDKRLNSIGLENTEENRRKYR
Drosophila        MTTYFNYPSKELQDELREIAQKIVAPGKGILAADESGPTMGKRLQDIGVENTEDNRRAYR
Mus               MPHPYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR
Homo              MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYR

Arabidopsis       ELLFTSPGSY-PCLSGVILFEETLYQKTSDGKPFVDLLMENGVIPGIKVDKGLVDLAGTN
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       QLLFSADHKLAENISGVILFEETLHQKSDDGKTLPTLLAERNIIPGIKVDKGVVPLAGTD
Caenorhabditis    QLLFTAGADLNKYISGVIMFHETFYQKTDDGKPFTALLQEQGIIPGIKVDKGVVPMAGTI
Drosophila        QLLFSTDPKLAENISGVILFHETLYQKADDGTPFAEILKKKGIILGIKVDKGVVPLFGSE
Mus               QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTN
Homo              QLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTN

Arabidopsis       GETTTQGLDSLGARCQQYYEAGGRFAKWRAFFKIGATEPSVLSIQEDA-RVLARYAIICQ
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       NETTTQGLDDLASRCAEYWRLGCRFAKWRCVLKISSHTPSYLAMLENA-NVLARYASICQ
Caenorhabditis    GEGTTQGLDDLNARCAQYKKDGAQFAKWRCVHKISSTTPSVTALKEIASNLGSRYASICQ
Drosophila        DEVTTQGLDDLAARCAQYKKDGCDFAKWRCVLKIGKNTPSYQSILENA-NVLARYASICQ
Mus               GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENA-NVLARYASICQ
Homo              GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENA-NVLARYASICQ

Arabidopsis       ENGLVPIVEPEVLTGGSHDIKKCAAVTETVLAAVFKALNYHHVLLEGTLLKPNMVTPGSD
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       QNGLVPIVEPEVLPDGDHDLLTAQRVTEQVLAFVYKALADHHVYLEGTLLKPNMVTAGQA
Caenorhabditis    QNGLVPIVEPEILPDGEHCLARGQKITETVLSYVYHALNEHHVFLEGTLLKPNMVTSGQS
Drosophila        SQRIVPIVEPEVLPDGDHDLDRAQKVTETVLAAVYKALSDHHVYLEGTLLKPNMVTAGQS
Mus               QNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHA
Homo              QNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHA

Arabidopsis       S--PKVAPELIAEYTVTALRRTVPPAIPGIVFLSGIQREEQATLNLNAMNKLDVLKPWTL
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       CK-KAYTPQENALATVRALQRTVPPAVPGITFLSGGQSELDATKNLNEINKIPGPKPWAL
Caenorhabditis    FTGEKPSNADIGLATVTALQRGVPSAVPGVVFLSGGQSEEDATLNLNAINQVSGKKPWAL
Drosophila        A--KKNTPEEIALATVQALRRTVPAAVTGVTFLSGGQSEEEATVNLSAINNVPLIRPWAL
Mus               CT-QKFSNEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWAL
Homo              CT-QKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWAL

Arabidopsis       TFSFGGALQQSAIKAWAGKPENVAKAQAKFLTRCKANKDATLGKYTGWASGDSAAFENLV
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       TFSFGRALQASVLATWKGKKENVHAAQEELLKLAKANGAAAVGKFEGN-MGTTLGDKSLF
Caenorhabditis    TFSYGRALQASCLAKWAGKDENIAAAQEVLLHRAQVNSLASVGKYTGDASADAAASQSLF
Drosophila        TFSYGRALQASVLRAWAGKKENIAAGQNELLKRAKANGEAACGNYTAGSVKGFAGKDTLH
Mus               TFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLF
Homo              TFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLF

Arabidopsis       VIGYRY
Saccharomyces     XXXXXX
Schistosoma       VANHAY
Caenorhabditis    VANHSY
Drosophila        VDDHRY
Mus               ISNHAY
Homo              VSNHAY


[Calreticulin]

Arabidopsis       ------------NSARASAAVIFEERF--DDGWENRWVKSEWKKDDNTAGEWKHTAGNWS
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       -MLSILLTL-LLSKYALGHEVWFSETF-PNESIEN-WVQSTYNAEK--QGEFKVEAGKSP
Caenorhabditis    -MKSLCL---LAIVAVVSAEVYFKEEF-NDASWEKRWVQSKHKDD---FGAFKLSAGKFF
Drosophila        MMWCKTVIVLLATVGFISAEVYLKENF-DNENWEDTWIYSKHPGKE--FGKFVLTPGTFY
Mus               MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSD---FGKFVLSSGKFY
Homo              MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSD---FGKFVLSSGKFY

Arabidopsis       GDA-NDKGIQTSEDYRFYAISAEF-PEFSNKDKTLVFQFSVKHEQKLDCGGGYMKLLSGD
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       VDPIEDLGLKTTQDARFYGIARKISEPFSNRGKTILLQFTVKFDKTVSCGGAYIKLLGSD
Caenorhabditis    DVESRDQGIQTSQDAKFYSRAAKFDKDFSNKGKTLVIQYTVKHEQGIDCGGGYVKVMRAD
Drosophila        NDAEADKGIQTSQDARFYAASRKF-DGFSNEDKPLVVQFSVKHEQNIDCGGGYVKLFDCS
Mus               GDLEKDKGLQTSQDARFYALSAKF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPSG
Homo              GDEEKDKGLQTSQDARFYALSASF-EPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNS

Arabidopsis       VDQKKFGGDTPYSIMFGPDICGYSTKKVHAILTYNGANHLIKKDVPCETDQLTHVYTFIL
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       IDPKKFHGESPYKIMFGPDICGMATKKVHVIFNYKGKNHLIKKEIPCKDDLKTHLYTLIV
Caenorhabditis    ADLGDFHGETPYNVMFGPDICGP-TRRVHVILNYKGENKLIKKEITCKSDELTHLYTLIL
Drosophila        LDQTDMHGESPYEIMFGPDICGPGTKKVHVIFSYKGKNHLISKDIRCKDDVYTHFYTLIV
Mus               LDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIV
Homo              LDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIV

Arabidopsis       RPDATYSILIDNVEKQTGSLYSDWDLLPPKKIKDPSAKKPEDWDEQEYISDPEDKKTDGY
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       NPNNKYEVLVDN------A--------------DPNDKKPDDWVDEQFIDDPDDKKPDNW
Caenorhabditis    NSDNTYEVKIDGESAQTGSLEEDWDLLPAKKIKDPDAKKPEDWDEREYIDDAEDAKPEDW
Drosophila        RPDNTYEVLIDNEKVESGNLEDDWDFLAPKKIKDPTATKPEDWDDRATIPDPDDKKPEDW
Mus               RPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDW
Homo              RPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDW

Arabidopsis       DDIPKEIPDTDSKKPEDWDDEEDGEWTAPTIPNPEYMGEWKPKQIKNPNYKGKWEAPLID
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       DQ-PKTIPDMDAKKPDDWDDAMDGEWERPQKDNPEYKGEWTPRRIDNPKYKGEWKPVQID
Caenorhabditis    EK-PEHIPDPDAKKPEDWDDEMDGEWEPPMIDNPEYKGEWKPKQIKNPAYKGKWIHPEIE
Drosophila        DK-PEHIPDPDATKPEDWDDEMDGEWEPPMIDNPEFKGEWQPKQLDNPNYKGAWEHPEIA
Mus               DK-PEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEID
Homo              DK-PEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEID

Arabidopsis       NPDFKDDPELYVFPKLKYVGLELWQVKSGSLFDNVLICDDPDYAKKLADETWGKLKDAEK
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       NPEYKHDPELYVLNDIGYVGFDLWQVDSGSIFDNILITDSPDFAKEEGERLWRKRYDAEV
Caenorhabditis    NPEYTPDDELYSYESWGAIGFDLWQVKSGTIFDNIIITDSVEEAEAHAAETFDKLKTVEK
Drosophila        NPEYVPDDKLYLRKEICTLGFDLWQVKSGTIFDNVLITDDVELAAKAAAEV-KNTQAGEK
Mus               NPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK
Homo              NPEYSPDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEK

Arabidopsis       AAFDEAEKKNEEEESKDAPAESDAEDEPEDDEGGDDSDSESKAEETKSEDSEETSEKDAT
Saccharomyces     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
Schistosoma       A----KEQSSAKDDKEEAEETKE-RKELP--------D------DAKASDEPSG---D--
Caenorhabditis    EKKEKADEETRKAEEEARKKAEE-EKEAK--KD----D------DEEEKEEEEG------
Drosophila        KMKEAQDEVQRKKDEEEAKKASD-KDDED--ED----DDDEEKDDESKQDKDQS---E--
Mus               QMKDKQDEEQRLKEEEEDKKRKE-EEEAEDKEDDDDRDEDEDEEDEKEEDEEES---PGQ
Homo              QMKDKQDEEQRLKEEEEDKKRKE-EEEAEDKEDDEDKDEDEEDEEDKEEDEEED--VPGQ

Arabidopsis       AHDEL
Saccharomyces     XXXXX
Schistosoma       -HDEL
Caenorhabditis    -HDEL
Drosophila        -HDEL
Mus               AKDEL
Homo              AKDEL


[Elongation factor 1-alpha]

Arabidopsis       MGKEKFHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVL
Saccharomyces     MGKEKSHINVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVL
Schistosoma       MPSDKEHINIVVYGHVDSGKSTTTGHLIFKCGGIDKRAIEKYEKESGEMGKGSFKYAWVL
Caenorhab         MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVL
Drosophila        MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVL
Mus               MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL
Homo              MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVL

Arabidopsis       DKLKAERDRGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTT
Saccharomyces     DKLKAERERGITIDIALWKFETPKYQVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGV
Schistosoma       VKLKAERERGITIDIVLWKFDTQTYKVTVIDAPGHRDFTTNMITGTSQADCAVLIVAAGV
Caenorhab         DKLKAERERGITIDIALWKFETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGT
Drosophila        DKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVQIDAAGT
Mus               DKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV
Homo              DKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGV

Arabidopsis       GGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKARYDEIIKEVSSYLKK
Saccharomyces     GEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDSVK--WDESRFQEIVKETSNFIKK
Schistosoma       GEFEAGISKNGQTREHALLAYTLGVKQLIIAINKMDCTEPPFSEDRYKEIVKEVSGYIKK
Caenorhab         GEFEAGISKNGQTREHALLAQTLGVKQLIVACNKMDSTEPPFSEARFTEITNEVSGFIKK
Drosophila        GEFEAGISKNDQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKK
Mus               GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPAYSEKRYDEIVKEVSAYIKK
Homo              GEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKK

Arabidopsis       VGYNPDKIPFVPISGFEGDNMIERSTNLDWYK----------------GPTLLEALDQIN
Saccharomyces     VGYNPKTVPFVPISGWNGDNMIEATTNAPWYKGWEKET-KAGVVK---GKTLLEAIDAIE
Schistosoma       VGYNPATVPFVPISGWHGDNMIEKSSFMPWFKGWEITRTKDGKTVTDTGFTLLEALDKME
Caenorhab         IGYNPKAVPFVPISGFNGDNMLEVSSNMPWFKGWAVER-KEGNAS---GKTLLEALDSII
Drosophila        VGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKGWEVGR-KEGNAD---GKTLVDALDAIL
Mus               IGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVER-KEGNAS---GVSLLEALDTIL
Homo              IGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTR-KDGNAS---GTTLLEALDCIL

Arabidopsis       EPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGMIKPGMVVTFAPTGLTTEVKSVEMHH
Saccharomyces     QPSRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVIKPGMVVTFAPAGVTTEVKSVEMHH
Schistosoma       PPARMTDKPLRIPLQDVYKIGGMGTVPVGRVETGIIKPGMVVTFGPQGWSAEVKSVEMHH
Caenorhab         PPQRPTDRPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPQNVTTEVKSVEMHH
Drosophila        PPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHH
Mus               PPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGMVVTFAPVNITTEVKSVEMHH
Homo              PPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHH

Arabidopsis       ESLLEALPGDNVGFNVKNVAVKDLKRGYVASNSKDDPAKGAANFTSQVIIMNHPGQIGNG
Saccharomyces     EQLEQGVPGDNVGFNVKNVSVKEIRRGNVCGDAKNDPPKGCASFNATVIVLNHPGQISAG
Schistosoma       EALTEGLPGSNVGFNVKNVAVSEIHRGNVAGDSKNDPPKEAESFMAQVIVLNHPGEIKNG
Caenorhab         ESLPEAVPGDNVGFNVKNVSVKDIRRGSVCSDSKQDPAKEARTFHAQVIIMNHPGQISNG
Drosophila        EALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANG
Mus               EALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKADPPQEAAQFTSQVIILNHPGQISAG
Homo              EALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAG

Arabidopsis       YAPVLDCHTSHIAVKFSEILTKIDRRSGKEIEKEPKFLKNGDAGMVKMTPTKPMVVETFS
Saccharomyces     YSPVLDCHTAHIACRFDELLEKNDRRSGKKLEDHPKFLKSGDAALVKFVPSKPMCVEAFS
Schistosoma       YSPVLDCHTAHIASKFSEITEKLDRRSGKKSEDNPKCIKNGDAANILLVPNKPLCLETFQ
Caenorhab         YTPVLDCHTAHIACKFNELKEKVDRRTGKKVEDFPKFLKSGDAGIVELIPTKPLCVESFT
Drosophila        YTPVLDCHTAHIACKFAEILEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQ
Mus               YSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPKSLKSGDAAIVEMVPGKPMCVESFS
Homo              YAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFS

Arabidopsis       EYPPLGRFAVRDMRQTVAVGVIKSVDKKDPTGAKVTKAAVKKGAK--
Saccharomyces     EYPPLGRFAVRDMRQTVAVGVIKSVDKTE-KAAKVTKAAQKAAKK--
Schistosoma       QYPPLGRFAVRDMNQTVAVGVVKSVTKKE-SAAKVTKSAAKVAKKK-
Caenorhab         DYAPLGRFAVRDMRQTVAVGVIKSVEKSDGSSGKVTKSAQKAAPKKK
Drosophila        EFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATKGKK
Mus               QYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGKVTKSAQKAQKAGK
Homo              DYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK-


[Enolase]

Arabidopsis       MATITVVKARQIFDSRGNPTVEVDIHTSNGIKVTAAVPSGASTGIYEALELRDGG-SDYL
Saccharomyces     M-AVSKVYARSVYDSRGNPTVEVELTTEKGV-FRSIVPSGASTGVHEALEMRDGDKSKWM
Schistosoma       M-SILTIHARQIFDSRGNPTVEVDLKTSKGL-FRAAVPSGASTGVHEALELRDTNSKAYM
Caenorhab         M-PITKIHARQIYDSRGNPTVEVDLFTEKGV-FRAAVPSGASTGVHEALELRDGDKAVHL
Drosophila        M-TIKAIKARQIYDSRGNPTVEVDLTTELGL-FRAAVPSGASTGVHEALELRDNDKANYH
Mus               M-SILRIHAREIFDSRGNPTVEVDLYTAKGL-FRAAVPSGASTGIYEALELRDNDKTRFM
Homo              M-SILKIHAREIFDSRGNPTVEVDLFTSKGL-FRAAVPSGASTGIYEALELRDNDKTRYM

Arabidopsis       GKGVSKAVGNVNNIIGPALIGK--DPTQQTAIDNFMVHELDGTQNEWGWCKQKLGANAIL
Saccharomyces     GKGVLHAVKNVNDVIAPAFVKANIDVKDQKAVDDFLI-SLDGTAN-----KSKLGANAIL
Schistosoma       KKGVLTAVSNVNKIIAPALINKNIPVTNQAAIDKYMI-DLDGTEN-----KEKLGANAIL
Caenorhab         GKGVLKAVSNINEKIAPALIAKGFDVTAQKDIDDFMM-ALDGSEN-----KGNLGANAIL
Drosophila        GKSVLKAVGHVNDTLGPELIKANLDVVDQASIDNFMI-KLDGTEN-----KSKFGANAIL
Mus               GKGVSQAVEHINKTIAPALVSKKVNVVEQEKIDKLMI-EMDGTEN-----KSKFGANAIL
Homo              GKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMI-EMDGTEN-----KSKFGANAIL

Arabidopsis       AVSLAVCKAGAVVSGIPLYKHIANLAGN--PKIVLPVPAFNVINGGSHAGNKLAMQEFMI
Saccharomyces     GVSLAASRAAAAEKNVPLYKHLADLSKSKTSPYVLPVPFLNVLNGGSHAGGALALQEFMI
Schistosoma       GVSLAVCKAGAAEAGLPLYRYIARLAGH--EDVIMPVPAFNVINGGSHAGNKLAMQEFMI
Caenorhab         GVSLAVAKAGAVHKGLPLYKYIAELAGT--GKVVLPVPAFNVINGGSHAGNKLAMQEFMI
Drosophila        GVSLAVAKAGAAKKGVPLYKHIADLAGN--KEIILPVPAFNVINGGSHAGNKLAMQEFMI
Mus               GVSLAVCKAGAVEKGVPLYRHIADLAGN--PEVILPVPAFNVINGGSHAGNKLAMQEFMI
Homo              GVSLAVCKAGAVEKGVPLYRHIADLAGN--SEVILPVPAFNVINGGSHAGNKLAMQEFMI

Arabidopsis       LPVGAASFKEAMKMGVEVYHHLKSVIKKKYGQDATNVGDEGGFAPNIQENKEGLELLKTA
Saccharomyces     APTGAKTFAEALRIGSEVYHNLKSLTKKRYGASAGNVGDEGGVAPNIQTAEEALDLIVDA
Schistosoma       LPTGASSFTEAMQIGTEVYHNLKAVIKREYGLDACNVGDEGGFAPNIQDNMKGLQLLEEA
Caenorhab         LPVGASSFAEAMRMGSEVYHHLKAEIKKRYGLDATAVGDEGGFAPNIQDNKEGLDLLNTA
Drosophila        LPTGATSFTEAMKMGSEVYHHLKNVIKAKFGLDATAVGDEGGFAPNIQSNKEALNLISDA
Mus               LPVGASSFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEALELLKTA
Homo              LPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTA

Arabidopsis       IEKAGYTGKVVIGMDVAASEFYSEDKTYDLNFKEENNNGSQKISGDALKDLYKSFVAEYP
Saccharomyces     IKAAGHDGKVKIGLDCASSEFFKDGK-YDLDFKNPNSDKSKWLTGPQLADLYHSLMKRYP
Schistosoma       IKIAGYTGKVEIGMDCAASEFHKNGK-YDLDFKNPHSAESTWLSPDAMANMYKQMISKFP
Caenorhab         IDKAGYTGKISIGMDVAASEFFKDGK-YDLDFKNPASDSSKWLSGEQLTELYQSFIKEYP
Drosophila        IAKAGYTGKIEIGMDVAASEFYKDGQ-YDLDFKNEKSDKSQWLPADKLANLYKEFIKDFP
Mus               IAKAGYTDQVVIGMDVAASEFYRSGK-YDLDFKSP-DDPSRYITPDQLADLYKSFVQNYP
Homo              IGKAGYTDKVVIGMDVAASEFFRSGK-YDLDFKSP-DDPSRYISPDQLADLYKSFIKDYP

Arabidopsis       IVSIEDPFDQDDWEHYAKMTTECGTEVQIVGDDLLVTNPKRVAKAIAEKSCNALLLKVNQ
Saccharomyces     IVSIEDPFAEDDWEAWSHFFKTAG--IQIVADDLTVTNPKRIATAIEKKAADALLLKVNQ
Schistosoma       IVSIEDPFDQDDWETWPKLTSSTN--IQIVGDDLTVTNPKRIKQAIASKACNCLLLKVNQ
Caenorhab         VVSIEDAFDQDDWDNWGKFHGATS--IQLVGDDLTVTNPKRIQTAIDKKSCNCLLLKVNQ
Drosophila        IVSIEDPFDQDHWEAWSNLTGCTD--IQIVGDDLTVTNPKRIATAVEKKACNCLLLKVNQ
Mus               VVSIEDPFDQDDWGAWQKFTASAG--IQVVGDDLTVTNPKRIAKAASEKSCNCLLLKVNQ
Homo              VVSIEDPFDQDDWGAWQKFTASAG--IQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQ

Arabidopsis       IGSVTESIEAVKMSKKAGWGVMTSHRSGETEDTFIADLAVGLSTGQIKTGAPCRSERLAK
Saccharomyces     IGTLSESIKAAQDSFAAGWGVMVSHRSGETEDTFIADLVVGLRTGQIKTGAPARSERLAK
Schistosoma       IGSLTESIEACKLAQDSGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSDRLAK
Caenorhab         IGSVTESIEAAKLSRANGWGVMVSHRSGETEDTFIADLVVGLATGQIKTGAPCRSERLAK
Drosophila        IGTVTESIAAHLLAKKNGWGTMVSHRSGETEDSFIGDLVVGLSTGQIKTGAPCRSERLAK
Mus               IGSVTESLQACKPAQSNGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAK
Homo              IGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAK

Arabidopsis       YNQLLRIEEELGSEAIYAGVNFRKPVEPY
Saccharomyces     LNQLLRIEEELGDNAVFAGENFHHGDKL-
Schistosoma       YNQLLRIEEELGTAAKYAGKNFRHPKV--
Caenorhab         YNQLLRIEEELGADAVYAGHNFRNPQV--
Drosophila        YNQILRIEEEIGAGVKFAGKSFGKPQ---
Mus               YNQILRIEEELGSKAKFAGRSFRNPLAK-
Homo              YNQLLRIEEELGSKAKFAGRNFRNPLAK-


[Glyceraldehyde-3-phosphate dehydrogenase]

Arabidopsis       MASVTFSVPKGFTEFSGLRSSSASLPFGKKLSSDEFVSIVSFQTSAMGSSGGYRKGVTEA
Saccharomyces     ------------------------------------M-----------------------
Schistosoma       ------------------------------------MS----------------------
Caenorhab         ------------------------------------MS----------------------
Drosophila        ------------------------------------M-----------------------
Mus               ------------------------------------M-----------------------
Homo              ------------------------------------MG----------------------

Arabidopsis       KLKVAINGFGRIGRNFLRCWHGRKDSPLDIIAINDTG-GVKQASHLLKYDSTLGIFDADV
Saccharomyces     -VRVAINGFGRIGRLVMRI--ALSRPNVEVVALNDPFITNDYAAYMFKYDSTHGRYAGEV
Schistosoma       KAKVGINGFGRIGRLVLRA--AFLKNTVDIVAVNDPFIDLEYMVYMIKYDSTHGKFQGDV
Caenorhab         KANVGINGFGRIGRLVLRA--AVEKDTVQVVAVNDPFITIDYMVYLFKYDSTHGQFKGTV
Drosophila        -SKIGINGFGRIGRLVLRA--AIDKG-ASVVAVNDPFIDVNYMVYLFKFDSTHGRFKGTV
Mus               -VKVGVNGFGRIGRLVTRA--AICSGKVEIVAINDPFIDLNYMVYMFQYDSTHGKFNGTV
Homo              KVKVGVNGFGRIGRLVTRA--AFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTV

Arabidopsis       KPSGETAISV--DGK---IIQVVSNRNPSLLPWKELGIDIVIEGTGVFVDREGAGKHMEA
Saccharomyces     SHDDKH-IIV--DGK---KIATYQERDPANLPWGSSNVDIAIDSTGVFKELDTAQKHIDA
Schistosoma       SVENGK-LNV--NGR---LISVYCERDPLNIPWNKDGAEYVVESTGVFTTIDKAQAHIKN
Caenorhab         TYDGDF-LIVQKDGKSSHKIKVFNSKDPAAIAWGSVKADFVVESTGVFTTKEKASAHLQG
Drosophila        AAEGGF-LVV--NGQ---KITVFSERDPANINWASAGAEYVVESTGVFTTIDKASTHLKG
Mus               KAENGK-LVI--NGK---PITIFQERDPTNIKWGEAGAEYVVESTGVFTTMEKAGAHLKG
Homo              KAENGK-LVI--NGN---PITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQG

Arabidopsis       G-AKKVIITAPGKGDIPTYVVGVNADAYSHDEP-IISNASCTTNCLAPFVKVLDQKFGII
Saccharomyces     G-AKKVVITAP-SSTAPMFVMGVNEVKYTSDLK-IVSNASCTTNCLAPLAKVINDAFGIE
Schistosoma       DRAKKVIISAP-SADAPMFVVGVNEKTYDKSMS-VVSNASCTTNCLAPLAKVINDNFEIV
Caenorhab         G-AKKVIISAP-SADAPMYVVGVNHEKYDASNDHVVSNASCTTNCLAPLAKVINDNFGII
Drosophila        G-AKKVIISAP-SADAPMFVCGVNLDAYSPDMK-VVSNASCTTNCLAPLAKVINDNFEIV
Mus               G-AKRVIISAP-SADAPMFVMGVNHEKYDNSLK-IVSNASCTTNCLAPLAKVIHDNFGIV
Homo              G-AKRVIISAP-SADAPMFVMGVNHEKYDNSLK-IISNASCTTNCLAPLAKVIHDNFGIV

Arabidopsis       KGTMTTTHSYTGDQRLLDA-SHRDLRRARAAALNIVPTSTGAAKAVALVLPNLKGKLNGI
Saccharomyces     EGLMTTVHSLTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGM
Schistosoma       EGLMTTVHSFTATQKTVDGPSSKLWRDGRGAFQNIIPASTGAAKAVGKVIPALNGKLTGM
Caenorhab         EGLMTTVHAVTATQKTVDGPSGKLWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKLTGM
Drosophila        EGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPAATGAAKAVGKVIPALNGKLTGM
Mus               EGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGM
Homo              EGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELDGKLTGM

Arabidopsis       ALRVPTPNVSVVDLVVQVSKKTFAEEVNAAFRDSAEKELKGILDVCDEPLVSVDFRCSDF
Saccharomyces     AFRVPTVDVSVVDLTVKLDKETTYDEIKKVVKAAAEGKLKGVLGYTEDAVVSSDFLGDSH
Schistosoma       AFRVPTANVSVVDLTCRLGKGATYDQIKAVIKAAANGPLKGILEYTEDEVVSSDFIGCTS
Caenorhab         AFRVPTPDVSVVDLTVRLEKPASMDDIKKVVKAAADGPMKGILAYTEDQVVSTDFVSDPH
Drosophila        AFRVPTPNVSVVDLTVRLGKGATYDEIKAKVEEASKGPLKGILGYTDEEVVSTDFLSDTH
Mus               AFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSH
Homo              AFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTH

Arabidopsis       STTIDSSLTMVMGDDMVKVIAWYDNEWGYSQRVVDLADIVANNWK-
Saccharomyces     SSIFDASAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHIAKA---
Schistosoma       SSIFDAKAGISLNNNFVKLVSWYDNEFGYSCRVVDLITHMHRVDHS
Caenorhab         SSIFDAGACISLNPNFVKLVSWYDNEYGYSNRVVDLIGYIATRG--
Drosophila        SSVFDAKAGISLNDKFVKLISWYDNEFGYSNRVIDLIKYMQSKD--
Mus               SSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE--
Homo              SSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE--


[3-hydroxy-3-methylglutaryl coenzyme A reductase
HMG-CoA reductase]

Arabidopsis       ---MD--LRRR----P---PKPP------VTN-NNNSN--------GS-----------F
Saccharomyces     MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVF
Schistosoma       ---MLKILNTV----L---LFFDCFSTGTFFV-LLIYLFTRLRT--HLLH---------F
Caenorhab         ---MI--LKTS----A---SIVKS-----RGG-ILSAF--------CF-----------F
Drosophila        ---MIGPLFRA----T---QFCASHPWEVIVA-LLTITACMLNG--GQEQ---------Y
Mus               ------------------------------------------------------------
Homo              ---MLSRLFRMH---G---LFVASHPWEVIVG-TVTLTICMMSM--NM-----------F

Arabidopsis       ---RSYQ-----------PRTS--------------------------------D-----
Saccharomyces     ETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPHHYYLLNLNFNSPNETDSI
Schistosoma       ---SSSN----------CHLDVIIYQ-------SRAVI----------------IFLVVF
Caenorhab         ---YFCR-----------YR----------------------------------F-----
Drosophila        ---PGCE-----QRIGHSTASAAAAG---SGSGAGSGA----------------SGTIPP
Mus               ------------------------------------------------------------
Homo              ---TGNN-----------KICGWNYE-----------C----------------PKFEE-

Arabidopsis       -----------------------DDHRRRA--------------T---------------
Saccharomyces     PELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYDVFSE
Schistosoma       VYFIGVLT----CKI--------NDKI-LV--------------H-----------TMLR
Caenorhab         -----------------------YINLMNI--------------Y---------------
Drosophila        SSMGGSATS---SRHRPCHGW--SQSCDGLEAE-----------Y-------NAADVILM
Mus               ------------------------------------------------------------
Homo              ------------DVL--------SSDI-II--------------L---------------

Arabidopsis       TIAPP---------PKA--------------SD-----ALPLP---LYLTN---------
Saccharomyces     NVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLALYVTQ
Schistosoma       NKRQL---------NTLFYTLI----LFTF-ALCSLSSVLFVP--YTSFAIFLLSTSVF-
Caenorhab         FLNNP---------ISV--------------VR------STLA---SGNQN---------
Drosophila        TIVRC---------TAVLYCYY----QFCSLHRLGSKYVLGIAGLFTVFSSFIFTTAIIK
Mus               ------------------------------------------------------------
Homo              TITRC---------IAILYIYF----QFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIH

Arabidopsis       -AVFFT-----LFFSVAYYLLH----------------------------------R-WR
Saccharomyces     CILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKF-ERVGLSKRITTDEIVFESVS
Schistosoma       -LLFSDLSV--FFIVLEYYLLEIELVNYEHAKRHCLLSHLFSNQLFVDHMLGMFL-KTSL
Caenorhab         -IMVAD-----KRKLLDFLQSC----------------------------------D-IS
Drosophila        -FLGSDISE--LKDALFFLLLVIDLSNSGRLRSGAMGSN--QAEVTQNIARGLEL-LGPA
Mus               ------------------------------------------------------------
Homo              -FLDKELTG--LNEALPFFLLLIDLSRASTLAKFALSSN-SQDEVRENIARGMAI-LGPT

Arabidopsis       DKIRYNTP----LHV---------VTITELG--------------------------AII
Saccharomyces     EEGGRLIQDHLLCIFAFI-GCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILALR
Schistosoma       FSISTTSK---YAYLESIFKCTLMEQIIYIMIVFVFLPSFMRIFASYAKRMYGEQKKCLV
Caenorhab         DEASRKIE----NFI---------CENYDQK--------------------------E--
Drosophila        ISLDTIVV----VLLVGV-GTLSGVQRLEVLCMFAVLSVLVNYVVFM---TFYPACLSLI
Mus               ------------------------------------------------------------
Homo              FTLDALVE----CLVIGV-GTMSGVRQLEIMCCFGCMSVLANYFVFM---TFFPACVSLV

Arabidopsis       --AL----------------IASF------------------------------------
Saccharomyces     LEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLFVF
Schistosoma       SNKGV---SSSTRKRRHSYSSGHSYVEYRRMSVHNLIGYVVNPNCHYKCWSTT-FVIFVS
Caenorhab         --KP----------------KRKP------------------------------------
Drosophila        FDLSR---SGVDMSVVREKAKGSLPLKSLTEEEQKANPVLQRVKL---IMTTG-------
Mus               ------------------------------------------------------------
Homo              LELSR---ES--REGRPIWQLSHF-ARVLEEEENKPNPVTQRVKM---IMSLG-------

Arabidopsis       IYLLGF----FGIDF----------------V----------QS------FI-------S
Saccharomyces     INFYNFGANWVNDAF-NSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLL-YYKPIKS
Schistosoma       LIILHLNNRYSERIS-SFKHNSSENEVFP--VLYHITAYEV-TSIFHFIYNI--FHVINA
Caenorhab         LFSVG-----EDDDS---------------------------EE------YV-------S
Drosophila        LMAVHIYSREVSPAA--TTMVDKTLT-PT--LSLNVSNNRT-ESGEIADIII-KWLTMSA
Mus               ------------------------------------------------------------
Homo              LVLVHAHSRWIADPSPQNSTADTSKVSLG--LDENVSKRIE-PSVSLWQFYLSKMISMDI

Arabidopsis       R----------------AS-------------G-------------DAW------DLAD-
Saccharomyces     YQRIEDMVLLLLRNVSVAI--RDRFVSKLVLSALVC-SAVINVYLLNAA-RIHTSYTADQ
Schistosoma       NLVVYLFLGLFL-FKRIRL--NKPINSQLRNLN-I--PKIKETLISDQV-KQSPVLPKFS
Caenorhab         P----------------IK---------------------------ETC------ETGT-
Drosophila        DHIVISIVLIALVVKFICFDNRDPLPDQLRQSG----PVAIEAKASQTT----PIDEEHV
Mus               ------------------------------------------------------------
Homo              EQVITLSLALLLAVKYIFF-EQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNN

Arabidopsis       -TIDDDD---------HRLV------TCSPPTPI----V----SVAKLP----NPEPIV-
Saccharomyces     LVKTEVTKKSFTAPVQKASTPVLTNKTVISGSKVKSLSSAQSSSSGPSSSSEEDDSRDIE
Schistosoma       KKLNDIPLQS---RKRIYCLHKDDDYIDRNDSSS----VSTFSNTCKNSNE--RPSNVLD
Caenorhab         QCKRDVE---------YPEI--------ESGNR----------SLDEIS----REWKEC-
Drosophila        EQEKDTENSA---AVRTLLFTIEDQSSANASTQTD---LLPLRHRLVGPIKPPRPVQEC-
Mus               ------------------------------------------------------------
Homo              QKCDSVEEET--GINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIE

Arabidopsis       -TESL--P-EE----------------DEEIVKSVIDG--VIPSYSLESRLGDCKRAASI
Saccharomyces     SLDKKIRPLEELEALLSSGNT--KQLKNKEVAALVIHG--KLPLYALEKKLGDTTRAVAV
Schistosoma       -LDMLTEKIKQ-----GLGHE----LSDTEILQLLSHG--RLKTRELESVVRNPFRAVEL
Caenorhab         -KDVT--P--G------------------EAVRLLRRG--QAKSRELESRF-PAEQAIPI
Drosophila        -LDIL-NSTEE-----GSGPA---ALSDEEIVSIVHAGGTHCPLHKIESVLDDPERGVRI
Mus               ------------------------------------------------------------
Homo              -LPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAK--HIPAYKLETLMETHERGVSI

Arabidopsis       RREALQRVTGR---SIEGLPLDGFDYESILGQCCEMPVGYIQIPVGIAGPLLLDGY-EYS
Saccharomyces     RRKALSILAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGT-SYH
Schistosoma       RRLDLSTFLNNPH-IIERIPYKDYDYRLVYGQCCEEVIGYMPIPVGKIGPLLLDGR-SHY
Caenorhab         RRTFINK-------KFENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIY
Drosophila        RRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVLGYVPIPVGYAGPLLLDGE-TYY
Mus               ------------------------------------------------------------
Homo              RRQLLSKKLSEPS-SLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEK-EFQ

Arabidopsis       VPMATTEGCLVASTNRGCKAMFISGGATSTVLKDGMTRAPVVRFASARRASELKFFLENP
Saccharomyces     IPMATTEGCLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSE
Schistosoma       IPLATTEGCLVASTNRGCRAIFLAGGIKSVVYRDQMTRAPVVWFPSIIDSVKCIAWIDSE
Caenorhab         VPMATTEGALIASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHP
Drosophila        VPMATTEGALVASTNRGCKALSVRG-VRSVVEDVGMTRAPCVRFPSVARAAEAKSWIEND
Mus               ------E-----------KAL---------------------------------------
Homo              VPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETS

Arabidopsis       ENFDTLAVVFNRSSRFARLQSVKCTIAGKNAYVRFCCSTGDAMGMNMVSKGVQNVLEYLT
Saccharomyces     EGQNAIKKAFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMV
Schistosoma       EGFQTLKSAFDKTSAHVNLLSVFACPAGRYIHIRFAARTGDAMGMNMVSKATDSALHCLK
Caenorhab         ENQDRARQEFQSCSRFAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLM
Drosophila        ENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAITGDRMGMNMVSKALRWPFAEFT
Mus               --------------------------------LK------------------------LQ
Homo              EGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLH

Arabidopsis       DDF--PDMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAVIRGEIVNKVLKTSVAALVE
Saccharomyces     EEYGWEDMEVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVE
Schistosoma       KYF--SNMQVISLSGNMCTDKKPATINTILGRGKSVIAEAHLSADVLAQVLHTNAQRLAR
Caenorhab         ENF--PEMTVLALSGNLCVDKKAAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAY
Drosophila        LHF--PDMQIISLSGNFCCDKKPAAINWIKGRGKRVVTECTISAATLRSVLKTDAKTLVE
Mus               EFF--PDMQILAVSGNYCTDKKPAAINWIEGRGKTVVCEAVIPAKVVREVLKTTTEAMVD
Homo              EYF--PEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIE

Arabidopsis       LNMLKNLAGSAVAGSLG--GFNAHASNIVSAVFIATGQDPAQNVESSQCITMMEAIN-DG
Saccharomyces     LNIAKNLVGSAMAGSVG--GFNAHAANLVTAVFLALGQDPAQNVESSNCITLMK-EV--D
Schistosoma       LTHSKNWIGSAMAGCPGMMGCNAHAANIIAGMFAATGQDLAQVVDSSSCLTQLEVDL-SD
Caenorhab         LTTTKLHIGSSRAGAVG--GSNAHAANIVAAIFIATGQDAAQVVSSSMCSTRMEVTA--D
Drosophila        CNKLKNMGGSAMAGSIG--GNNAHAANMVTAVFLATGQDPAQNVTSSNCSTAMECWAENS
Mus               VNINKNLVGSAMAGSIG--GYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTN
Homo              VNINKNLVGSAMAGSIG--GYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTN

Arabidopsis       KDIHISVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASTESPGMNARRLATIVAGAVLA
Saccharomyces     GDLRISVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLA
Schistosoma       DSLVASVTMPCLEVGTVGGGTRLSGQRACLDLLDL---SVDRPTEH---LSRIIAGTVLA
Caenorhab         KNLYVSCTLPCVEVGTVGGGTILAPQRACLESLGCAGPNKEQPGQNAERLAEVIAATVLA
Drosophila        EDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHATRPGDNAKKLAQIVCATVMA
Mus               EDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMA
Homo              EDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMA

Arabidopsis       GELSLMSAIAAGQLVRSHMKYNRSS-------------------R-----DISGA-TTTT
Saccharomyces     GELSLCAALAAGHLVQSHMTHNRKP-------------------AEPTKPNNLDA-TDIN
Schistosoma       AELSLMAALDTDDLVKAHMHFNRAKQSTNSHSCSHSTTTDNNDNISNIYDNHNVALSSKI
Caenorhab         GELSLMAALTTNELVSSHMKLNRSK---------QQLYADDSGKATHFEKEVEKA-GSLL
Drosophila        GELSLMAALVNSDLVKSHMRHNRSS-------------------I-----AVNSA-NNPL
Mus               GELSLMAALAAGHLVRSHMVHNRSK-------------------I-----NLQDL-QGTC
Homo              GELSLMAALAAGHLVKSHMIHNRSK-------------------I-----NLQDL-QGAC

Arabidopsis       TT-----------------TT----------------
Saccharomyces     RLKDGSV------------TCIKS-------------
Schistosoma       PVTDNSDIRESVHSLHVKPFPVKSDLSVNPEISHYTM
Caenorhab         SGKSGNI--------KLKRLPQDV---V--QCSNIL-
Drosophila        NVTVSSC------------STIS--------------
Mus               TK-----------------KAA---------------
Homo              TK-----------------KTA---------------


[Phosphoglycerate kinase]

Arabidopsis       ----GDLT--SADLKGKKVFVRADLNVPLDDNQTITDDTRIRAAIPTIKYLIENGAK-VI
Saccharomyces     MSLSSKLSVQDLDLKDKRVFIRVDFNVPLDGKK-ITSNQRIVAALPTIKYVLEHHPRYVV
Schistosoma       MGL-SKLSISDVDLKGKRVLIRVDFNVPMKDGK-VTNTQRIAAAIPTIKYALDKGAKSVV
Caenorhab         MSSLNKLAIDQLNLAGKRVLIRVDFNVPLKDGK-ITNNQRIAAAVPTIQHALSNGAKSVV
Drosophila        MAF-NKLSIENLDLAGKRVLMRVDFNVPIKEGK-ITSNQRIVAALDSIKLALSKKAKSVV
Mus               MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQ-ITNNQRIKAAVPSIKFCLDNGANSVV
Homo              MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQ-ITNNQRIKAAVPSIKFCLDNGAKSVV

Arabidopsis       LSTHLGRPKG--VTPKFSLAPLVPRLSELLGIEVTKADDCIGPEVESLVASLPEGGVLLL
Saccharomyces     LASHLGRPNG-ERNEKYSLAPVAKELQSLLGKDVTFLNDCVGPEVEAAVKASAPGSVILL
Schistosoma       LMSHLGRPDG-HKVDKYSLKPVCPEVSKLLGKEVTFLNDCVGPDVVNACANPAPGSVFLL
Caenorhab         LMSHLGRPDG-RRQDKYTLKPVAEELKALLKKDVLFLDDCVGSEVEAACADPAPGSVILL
Drosophila        LMSHLGRPDG-NKNIKYTLAPVAAELKTLLGQDVIFLSDCVGSEVEAACKDPAPGSVILL
Mus               LMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGPEVENACANPAAGTVILL
Homo              LMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILL

Arabidopsis       ENVRFYKEEE-KN----------DP----EFAKKLASLADLYVNDAFGTAHRAHASTEGV
Saccharomyces     ENLRYHIEEEGSRK-VDGQKVKASKEDVQKFRHELSSLADVYINDAFGTAHRAHSSMVGF
Schistosoma       ENLRFHVEEEGKGVSPTGEKTKATADQIKAFSESLTKLGDVYVNDAFGTAHRAHASMVGC
Caenorhab         ENLRYHLEEEGKGVDASGAKVKADSAAVKKFRESLTKLGDIYVNDAFGTAHRAHSSMVGV
Drosophila        ENVRFYVEEEGKGLDASGGKVKADPAKVKEFRASLAKLGDVYVNDAFGTAHRAHSSMMGD
Mus               ENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGV
Homo              ENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGV

Arabidopsis       TKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLG
Saccharomyces     D--LPQRAAGFLLEKELKYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIG
Schistosoma       Q--LPQKACGFLMNKELTYFAKALENPERPFLAILGGAKVSDKIQLINNMLDKVNELIIG
Caenorhab         E--HSQRASGFLLKNELSYFSKALDNPARPFLAILGGAKVADKIQLIKNLLDKVNEMIIG
Drosophila        G--FEQRAAGLLLNKELKYFSQALDKPPNPFLAILGGAKVADKIQLIENLLDKVNEMIIG
Mus               N--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIG
Homo              N--LPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIG

Arabidopsis       GGMIFTFYK-AQGLSVGSSLVEEDKLELATELLAKAKAKGVSLLLPTDVVVADKFAPDAN
Saccharomyces     GGMAFTFKKVLENTEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFIIADAFSADAN
Schistosoma       GGMAYTFLKQIHNMHIGNSLFDAPGAEIVHKVMETAKAKNVAIHLPVDFVTADKFADDAN
Caenorhab         GGMAYTFLKVAQGVKIGNSLYDEEGAKIVNELLEAAKAKGVQIHLPVDFVIADKFAEDAT
Drosophila        GGMAFTFLKVLNNMKIGGSLFDEEGSKIVEKLVEKAKKNNVQLHLPVDFVCGDKFAENAA
Mus               GGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAK
Homo              GGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAK

Arabidopsis       SK-IVPASGIEDGWMGLDIGPDSIKTFNEALDTTQTVIWNGPMGVFEMEKFAAGTEAIAN
Saccharomyces     TKTVTDKEGIPAGWQGLDNGPESRKLFAATVAKAKTIVWNGPPGVFEFEKFAAGTKALLD
Schistosoma       TEIRTIQSGIADGWMGLDIGPKTIEEFSKVISRAKTIVWNGPMGVFEMDKFATGTKAAMD
Caenorhab         SKTVTAEEGVPDGHMGLDVGPESSKIFAAAIQRAKTIVWNGPAGVFEFDKFATGTKSLMD
Drosophila        VSEATVEAGIPDGHMGLDVGPKTRELFAAPIARAKLIVWNGPPGVFEFPNFANGTKSIMD
Mus               TGQATVASGIPAGWMGLDCGTESSKKYAEAVGRAKQIVWNGPVGVFEWEAFARGTKSLMD
Homo              TGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMD

Arabidopsis       KLAELSEKGVTTIIGGGDSVAAVEKVGVAGVMSHISTGGGASLELLEGKVLPGVIALDEA
Saccharomyces     EVVKSSAAGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELLEGKELPGVAFLSEK
Schistosoma       EVVKATKNGATTIIGGGDTATCCAKWDTEDKVSHVSTGGGASLELLEGKQLPGVVALTDA
Caenorhab         EVVKATAAGAITIIGGGDTATAAKKYNTEDKVSHVSTGGGASLELLEGKVLPGVDALSPA
Drosophila        GVVAATKNGTVSIIGGGDTASCCAKWNTEALVSHVSTGGGASLELLEGKTLPGVRALTSA
Mus               EVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNV
Homo              EVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI

Arabidopsis       IPVTV
Saccharomyces     K----
Schistosoma       H----
Caenorhab         Q----
Drosophila        -----
Mus               -----
Homo              -----


[Ribosomal protein l13e]
	
Arabidopsis       M--KHNNVIPNGHFKKHWQNYVKTWFNQPARKTRRRIARQKKAVKIFPRPTSGPLRPVVH
Saccharomyces     MAISKNLPILKNHFRKHWQERVKVHFDQAGKKVSRRNARAARAAKIAPRPLD-LLRPVVR
Schistosoma       MV-HGNDVLHHNHFRKKWQFMVKTWFNQPARKERRRQARKAKAQRIAPRPASGPLRPIVN
Caenorhab         MAPRGNQMLGNAHFRKHWHKRIKTWFDQPARKLRRRQNRQAKAVEIAPRPVAGLLRSVVR
Drosophila        MG-KGNNMIPNQHYHKWWQRHVKTWFNQPARKVRRHANRVKKAKAVFPRPASGALRPVVR
Mus               MAPSRNGMILKPHFHKDWQQRVDTWFNQPARKIRRRKARLAKARRIAPRPASGPIRPIVR
Homo              MAPSRNGMVLKPHFHKDWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVR

Arabidopsis       GQTLKYNMKVRTGKGFTLEELKAAGIPKKLAPTIGIAVDHRRKNRSLEGLQTNVQRLKTY
Saccharomyces     APTVKYNRKVRAGRGFTLAEVKAAGLTAAYARTIGIAVDHRRQNRNQEIFDANVQRLKEY
Schistosoma       CPTFRYNMKVRSGRGFSLQEVRAAGLNPKFARTIGIAVDHRRRNVSVEGLQRNVARLKAY
Caenorhab         CPQKRYNTKTRLGRGFSLQELKAAGISQAQARTIGIAVDVRRTNKTAEGLKANADRLKEY
Drosophila        CPTIRYHTKLRAGRGFTLEELKGAGIGANFAKTIGIAVDRRRKNKSLESRQRNIQRLKEY
Mus               CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLKEY
Homo              CPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQTNVQRLKEY

Arabidopsis       KTKLVIFPRRARKVKAGDSTPEELANATQVQGDYLPIVREKPTM-ELVKLTSEMKSFKAF
Saccharomyces     QSKIIVFPRDGKAPE-----AEQV-LSAAAT---FPIAQPATDV-EARAVQDNGE--SAF
Schistosoma       KAKLILFPLNPAKPQAMDAKADEVKKATQLRRPVLPITQRAKRL-KAHKPTSSELRYSAF
Caenorhab         KAKLILFPKKASAPKKGDSSAEELKVAAQLRGDVLPLSHTITFD-EPRQVTDAERKVEIF
Drosophila        RSKLILFPINEKKIRAGESSLEECKLATQLKGPVLPIKNEQPAVVEFREVTKDEKKFKAF
Mus               RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPIRNVYKKE-KARVITEEEKNFKAF
Homo              RSKLILFPRKPSAPKKGDSSAEELKLATQLTGPVMPVRNVYKKE-KARVITEEEKNFKAF

Arabidopsis       DKIRLERTNKR-HAGARAKRAAEAEKEE-------KK---
Saccharomyces     RTLRLARSEKK-FRGIREKRAREKAEAE-AEK---KK---
Schistosoma       HAIR-----QQ-----------------------------
Caenorhab         RLLRKERADKK-YRGKREKRAREAAEEN-------K----
Drosophila        ATLR-TRTDAR-LVGIRAKRAKEAAESEDAAKGDPKKAKK
Mus               ASLRMARANAPTLWQSEQKRAKEASEQR-CWK---RKN--
Homo              ASLRMARANAR-LFGIRAKRAKEAAEQD-VEK---KK---


[t-complex polypeptide 1 alpha subunit]

Arabidopsis       M-SISAQNPDIS----G-DRQSGQDVRTQNVMACQAVSNIVKTSLGPVGLDKMLVDDIGD
Saccharomyces     M-NFGSQTPTIVVLKEGTDASQGKGQIISNINACVAVQEALKPTLGPLGSDILIVTSNQK
Schistosoma       M-------LTLG----G-ERTSGESVRKQNVLAACSFANFVKTSLGPVGLDKMLVDDVGD
Caenorhab         MASAGDSILALT----G-KRTTGQGIRSQNVTAAVAIANIVKSSLGPVGLDKMLVDDVGD
Drosophila        M-STLASPLSIA----G-TRQSRRIVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGD
Mus               M----EGPLSVF----G-DRSTGEAVRSQNVMAAASIANIVKSSFGPVGLDKMLVDDIGD
Homo              M----EGPLSVF----G-DRSTGETIRSQNVMAAASIANIVKSSLGPVGLDKMLVDDIGD

Arabidopsis       VTITNDGATILRMLEVEHPAAKVLVELAELQDREVGDGTTSVVIVAAELLKRANDLVRNK
Saccharomyces     TTISNDGATILKLLDVVHPAAKTLVDISRAQDAEVGDGTTSVTILAGELMKEAKPFLEEG
Schistosoma       VTITNDGATILKLLDVEHPAAKILVQLAQLQDEEVGDGTTSVVILAAALLKNADELISRF
Caenorhab         VIVTNDGATILKQLEVEHPAGKVLVELAQLQDEEVGDGTTSVVIVAAELLKRADELVKQK
Drosophila        VTVTNDGATILRLLEVEHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQK
Mus               VTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQK
Homo              VTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQK

Arabidopsis       IHPTSIISGYRLAMRESCKYIEEKLVTKVEK--LGKVPLINCAKTSMSSKLISGDSDFFA
Saccharomyces     ISSHLIMKGYRKAVSLAVEKINELAVDITSEKSSGRELLERCARTAMSSKLIHNNADFFV
Schistosoma       VHPTTVINGYRLACREACKYIQEHMAYDVNK--LGKAGLINVARTAMSSKLINLDADMFS
Caenorhab         VHPTTIINGYRLACKEAVKYISENISFTSDS--IGRQSVVNAAKTSMSSKIIGPDADFFG
Drosophila        IHPTSIISGYRIACKEACKYISEHLTAPVDE--LGRDSLINIAKTSMSSKIIGADAEFFS
Mus               IHPTSVISGYRLACKEAVRYINENLIINTDE--LGRDCLINAAKTSMSSKIIGINGDYFA
Homo              IHPTSVISGYRLACKEAVRYINENLIVNTDE--LGRDCLINAAKTSMSSKIIGINGDFFA

Arabidopsis       NLVVEAVLSVKMTNQRGEIKYPIKGINILKAHGQSARDSYLLNGYALNTG---RAAQGMP
Saccharomyces     KMCVDAVLSLDRNDLDD------KLIGIKKIPGGAMEESLFINGVAFKKTFSYAGFEQQP
Schistosoma       QMAVDALMAVEVSGGPKGPVYPIKAVNILKAHGRSMSESMLIDGYALNCT---AASQQMP
Caenorhab         ELVVDAAEAVRVEN-NGKVTYPINAVNVLKAHGKSARESVLVKGYALNCT---VASQAMP
Drosophila        AMVVDAAQSVKITDPRGQAVYSIKAVNVLKAHGKSARESVLIPGYALNCT---IASQQMP
Mus               NMVVDAVLAVKYTDARGQPRYPVNSVNILKAHGRSQIESMLINGYALNCV---VGSQGMP
Homo              NMVVDAVLAIKYTDIRGQPRYPVNSVNILKAHGRSQMESMLISGYALNCV---VGSQGMP

Arabidopsis       LRVSPAKIACLDFNLQKTKMQLGVQVVVNDPRELEKIRQREADMTKERIEKLLKAGANVI
Saccharomyces     KKFNNPKILSLNVELELKAEKDNAEVRVEHVEDYQAIVDAEWQLIFEKLRQVEETGANIV
Schistosoma       RIIKKAKIAFLDFSLQKVKMKLGVQVVVKDPAQLEAIRQREADITKERIQKILNAGANVI
Caenorhab         LRVQNAKIACLDFSLMKAKMHLGISVVVEDPAKLEAIRREEFDITKRRIDKILKAGANVV
Drosophila        KKIVNAKIACHDFSLQKTKMKMGVQVLINDPDKLEAIRARELDITKERINMILGTGVNVV
Mus               KRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVI
Homo              KRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVI

Arabidopsis       LTTKGIDDMALKYFVEAGAIAVRRVRKEDMRHVAKATGATLVTTFADMEGEETFDPAHLG
Saccharomyces     LSKLPIGDLATQFFADRNIFCAGRVSADDMNRVIQAVGGSIQSTTSDIKPEH------LG
Schistosoma       LTTGGIDDLCMKYFVEVNAMAVRRCKKVDLKNMAKATGGQLIVSLADMEGDEVFDPTKLG
Caenorhab         LTTGGIDDLCLKQFVESGAMAVRRCKKSDLKRIAKATGATLTVSLATLEGDEAFDASLLG
Drosophila        LVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIAKATGAAFITSLTNMDGEESFDASMVG
Mus               LTTGGIDDMYLKYFVEAGAMAVRRVLKRDLKHVAKASGASILSTLANLEGEETFEVTMLG
Homo              LTTGGIDDMCLKYFVEAGAMAVRRVLKRDLKRIAKASGATILSTLANLEGEETFEAAMLG

Arabidopsis       SADEVVEERIADDDVILIKGTKTSSAVSLILRGANDYMLDEMERALHDALCIVKRTLESN
Saccharomyces     TCALFEEMQIGSERYNLFQGCPQAKTCTLLLRGGAEQVIAEVERSLHDAIMIVKRALQNK
Schistosoma       NAEEVSQERICDDELIILRGPKVHPSASIILRGANDFYVDEMERSLHDALLVVKRVLESK
Caenorhab         HADEIVQERISDDELILIKGPKSRTASSIILRGANDVMLDEMERSVHDSLCVVRRVLESK
Drosophila        EAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYCDEMERSVHDALCVVKRVLESK
Mus               QAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLELK
Homo              QAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLESK

Arabidopsis       TVVAGGGAVESALSVYLEHLATTLGSREQLAIAEFADALLIIPKVLAVNAAKDATELVAK
Saccharomyces     LIVAGGGATEMEVSKCLRDYSKTIAGKQQMIINAFAKALEVIPRQLCENAGFDAIEILNK
Schistosoma       RIVPGAGACETAVSIYLENYALTLSSREQLAIAEFARAMLSIPKQLAVNAGVDSTELVAR
Caenorhab         KLVAGGGAVETSLSLFLETYAQTLSSREQLAVAEFASALLIIPKVLASNAARDSTDLVTF
Drosophila        KVVRGGGCVEAALSIYLENFATSLASREQLAIAEFAKSLLVIPKTLSVNAAKDATDLVAK
Mus               SVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAK
Homo              SVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAK

Arabidopsis       LRAYHHTAQTKADKKHYSSMGLDLVNGTIRNNLEAGVIEPAMSKVKIIQFATEAAITILR
Saccharomyces     LRLAHSKGE--------KWYGVVFETENIGDNFAKFVWEPALVKINALNSATEATNLILS
Schistosoma       LRSCHNSSQSKPDQAHNKWWGLDLNNQYVADCKEIGVFEPLVSKIKSLKFATEAAITILR
Caenorhab         LRAYHSKAQLIPQLQHLKWAGLDLEEGTIRDNKEAGILEPALSKVKSLKFATEAAITILR
Drosophila        LRSYHNSSQTKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSKIKSLKFATEAAITILR
Mus               LRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILR
Homo              LRAFHNEAQVNPERKNLKWIGLDLSNGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILR

Arabidopsis       IDDMIKLV--KDE--SQGE--E---------
Saccharomyces     VDETITNKGSESANAGMMPPQGAGRGRGMPM
Schistosoma       IDDLIKLK--EEKQPDHDG--DECGY-----
Caenorhab         IDDLIKLD--KQE--PLGG--DDCHA-----
Drosophila        IDDMIKLN-PEDKSGKSYA--DACAAGELDG
Mus               IDDLIKLH-PESKDDKHGSYENAVHSGALDD
Homo              IDDLIKLH-PEILRIKHGSYEDAVHSGALND


[Triose phosphate isomerase]

Arabidopsis       MA--RKFFVGGNWKCNGTAEEVKKIVNTLNEAQVPSQDVVEVVVSPPYVFLPLVKSTLR-
Saccharomyces     MA--RTFFVGGNFKLNGSKQSIKEIVERLNTASIPEN--VEVVICPPATYLDYSVSLVKK
Schistosoma       MSGSRKFFVGGNWKMNGSRDDNDKLLKLLSEAHFDDN--TEVLIAPPSVFLHEIRKSLK-
Caenorhab         MT--RKFFVGGNWKMNGDYASVDGIVTFLNASADNSS--VDVVVAPPAPYLAYAKSKLK-
Drosophila        MS--RKFCVGGNWKMNGDQKSIAEIAKTLSSAALDPN--TEVVIGCPAIYLMYARNLLP-
Mus               MAPTRKFFVGGNWKMNGRKKCLGELICTLNAANVPAG--TEVVCAPPTAYIDFARQKLD-
Homo              MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPAD--TEVVCAPPTAYIDFARQKLD-

Arabidopsis       SDFFVAAQNCWVKKGGAFTGEVSAEMLVNLDIPWVILGHSERRAILNESSEFVGDKVAYA
Saccharomyces     PQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFA
Schistosoma       KEIHVAAQNCYKVSKGAFTGEISPAMIRDIGCDWVILGHSERRNIFGESDELIAEKVQHA
Caenorhab         AGVLVAAQNCYKVPKGAFTGEISPAMIKDLGLEWVILGHSERRHVFGESDALIAEKTVHA
Drosophila        CELGLAGQNAYKVAKGAFTGEISPAMLKDIGADWVILGHSERRAIFGESDALIAEKAEHA
Mus               PKIAVAAQNCYKVTNGPFTGEISPGMIKDLGATWVVLGHSERRHVFGESDELIGQKVSHA
Homo              PKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHA

Arabidopsis       LAQGLKVIACVGETLEEREAGSTMDVVAAQTKAIADRVT---NWSNVVIAYEPVWAIGTG
Saccharomyces     LGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVK---DWTNVVVAYEPVWAIGTG
Schistosoma       LAEGLSVIACIGETLSERESNKTEEVCVRQLKAIANKIKSADEWKRVVVAYEPVWAIGTG
Caenorhab         LEAGIKVVFCIGEKLEEREAGHTKDVNFRQLQAIVDKGV---SWENIVIAYEPVWAIGTG
Drosophila        LAEGLKVIACIGETLEEREAGKTNEVVARQMCAYAQKIK---DWKNVVVAYEPVWAIGTG
Mus               LAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVK---DWSKVVLAYEPVWAIGTG
Homo              LAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVK---DWSKVVLAYEPVWAIGTG

Arabidopsis       KVASPAQAQEVHDELRKWLAKNVSADVAATTRIIYGGSVNGGNCKELGGQADVDGFLVGG
Saccharomyces     LAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGG
Schistosoma       KVATPQQAQEVHNFLRKWFKTNAPNGVDEKIRIIYGGSVTAANCKELAQQHDVDGFLVGG
Caenorhab         KTASGEQAQEVHEWIRAFLKEKVSPAVADATRIIYGGSVTADNAADVGKKPDIDGFLVGG
Drosophila        KTATPDQAQEVHASLRQWLSDNISKEVSASLRIQYGGSVTAANAKELAKKPDIDGFLVGG
Mus               KTATPQQAQEVHEKLRGWLKSNVNDGVAQSTRIIYGGSVTGATCKELATPADVDGFLVGG
Homo              KTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGG

Arabidopsis       ASLKPEFIDIIKAAEVNKSA
Saccharomyces     ASLKPEFVDIINSRN-----
Schistosoma       ASLKPEFTEICKARQR----
Caenorhab         ASLKPDFVKIINARS-----
Drosophila        ASLKPEFLDIINARQ-----
Mus               ASLKPEFVDIINAKQ-----
Homo              ASLKPEFVDIINAKQ-----

;
END;

begin assumptions;
	exset *saved = 1-15 64-73 169-173 239-254 344-402 407-415 424-431 445-453 
	     	509-510 558-579 603-610 711-788 948-956 1004-1019 1237-1244 
         	1253-1266 1289-1294 1312-1319 1336-1346 1352-1358 1364-1368 1404-1413 
         	1520-1525 1532-1537 1572-1585 1701-1773 1786-1798 1803-1816 1828-1846
         	1885-1889 1899-1903 1916-1923 1966-1967 2104-2960 3031-3032 3065-3082 
         	3107-3122 3157-3246 3259-3265 3279-3288 3301-3305 3361-3380 3410-3419 
         	3480-3486 3530-3538 3647-3660 3706-3710 3784-3834 3840-3875 3876-3904 
		4019-4029 4062-4084 4102-4114 4214-4234 4361-4375 4421-4450 4476-4487 
		4494-4513 4597-4609 4697-4706 ;
endblock;