EEB 3895 Medical Parasitology Fall 2016

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EEB 3895 Medical Parasitology Fall 2016

Course description: Parasitic agents of human disease: protozoan, helminth, and arthropod parasites of medical importance and their basic morphology, classification, and life-cycles; diagnosis of infection; current topics in parasitic diseases.

Format : Class periods will include a blend of lectures and group activities.

Prerequisites: Three credits of introductory biology or approval of instructor.

Required text: Foundations of Parasitology 8th (2008; Roberts & Janovy) or 9th (2012; Roberts, Janovy & Nadler) edition; McGraw Hill.

Lecture: Mondays and Wednesdays, 9:05–10:20 am; Where: TLS Rm. 301

Instructor

Professor: Dr. J.N. Caira
office: TLS 483 (office hours by arrangement)
phone: 486-4060
email: Dr. Janine N. Caira

Important Documents

Schistosoma.jpg
Pdficon small.gif EEB 3895 Syllabus

Pdficon small.gif Classification Scheme



Course Objectives

The course is focused on the biology of the parasites responsible for human diseases. It is organized by parasite group and aims to provide:
(1) an overview of the major parasite taxa infecting humans globally,
(2) an appreciation of the diversity of life-cycles, portals of entry, sites infected, modes of reproduction these parasites employ, and
(3) a basic understanding of the pathology associated with, and diagnosis of, infection with each major parasite group.

Specific Learning Outcomes

The course will provide a sound parasitological foundation for students who wish to pursue a career in a medical or related academic field.
(1) Know fundamental concepts of parasitology and the technical vocabulary used in the field.
(2) Identify common human parasite taxa based on morphological, biological, clinical, and geographic criteria, and the diseases they cause.
(3) Understand the human body as a home to parasites in terms of portals of entry and exit, and sites occupied by parasites.
(4) Appreciate the complexity of parasite life-cycles and transmission strategies.
(5) Hone critical thinking skills by applying fact-based knowledge of human parasites to scenarios involving infection diagnosis and prevention.

Grading

3 Lecture Exams (90 points each) 270 points
Final Comprehensive Essay Exam 100 points
Class Participation (see * below) 30 points
TOTAL POSSIBLE POINTS: 400 points

Useful Websites

http://asp.unl.edu -The American Society of Parasitologists (general parasitology)
http://www.astmh.org -The American Society of Tropical Medicine and Hygiene (medical parasitology)
http://www.dpd.cdc.gov -Center for Disease Control (CDC) resource for identification of parasitic disease agents (US government infectious diseases surveillance agency; focused on human and zoonotic parasites)
http://www.who.int/neglected_diseases/diseases/en/ -World Health Organization (WHO) Programme on neglected tropical diseases (Note that 11 of the 17 targeted diseases deemed important globally are caused by parasitic organisms!)
http://www.who.int/topics/malaria/en/ -WHO Global Malaria Programme focusing on prevention, treatment and control of this protist infection

Past Exams

Pdficon small.gif Animal Parasitology Exam 1 2014

Study Guides

Pdficon small.gif Study Guide Exam 1

Lecture Schedule

This schedule is subject to change. Check regularly for updates!

Amoeba.jpg  Hookworm.jpg Tapewormsem.png Flea.jpg Echinoccocus.jpg Nematode.jpg  Mite.jpg Fluke.jpg Trypanosomasem.jpg 
* The course will include a series of in-class activities consisting of 10 Exercises (E1-E10 above) and 8 Skype conversations (S1-S8 above) with relevant parasite experts from around the country. Your grade for class participation will come from your participation in these activities. You must participate in at least 8 in-class Exercises (18 points). You will each also be asked to co-lead the Skype conversation with 1 of the 8 parasitologists (5 points), but will also be expected to be present for at least 7 of these conversations (7 points).
In-class Activity* Class Period Topic Readings
9th edition (8th edition)
M Aug 29 Introduction; General Concepts of Parasitology Ch 1 & 2 (both eds.)
E1 W Aug 31 The human body as a home to parasites; CDC & WHO
M Sep 05 Labor Day (no class)
Protozoan Diseases
W Sep 07 Introduction to zoonotic infections; Giardia: Giardiasis; Naegleria: PAM 88–92 (90–94); 116–119 (114–117)
M Sep 12 Entamoeba: Amoebiasis; Trichomoniasis 107–115 (105–113); 95–99 (93–97)
E2 W Sep 14 Trypanosoma: African Trypanosomiasis (Sleeping sickness) 61–70 (both eds.)
M Sep 19 Trypanosoma: American Trypanosomiasis (Chagas disease) 71–75 (71–76)
E3 W Sep 21 Leishmania: Leishmaniasis 77–85 (both eds.)
S1
Dr. Mary Ann McDowell (Leishmaniasis)
University of Notre Dame
M Sep 26 Plasmodium: Malaria 147–164 (143–159) & colour plates
W Sep 28 Plasmodium: Malaria 147–164 (143–159) & colour plates
M Oct 3 Exam I (Covers material up to end of Sept 28th)
E4 W Oct 5 Toxoplasma: Toxoplasmosis and related diseases 133–140 (131–137)
M Oct 10 Cryptosporidium: Cryptosporidiosis and related diseases 141–144 (122–123 & 140–141)
Helminth Diseases
E5 W Oct 12 Liver flukes: Fasciolosis; Clonorchiasis Ch 15 (both eds.); 268–273 (256–261); 287–292 (275–280)
M Oct 17 Lung flukes: Paragonimosis 281–285 (269–273)
S2
Dr. Kevin Lafferty
(Toxoplasmosis)
University of California-Santa Barbara
Dr. Lafferty interview
Pdficon small.gif Lafferty, 2006
Pdficon small.gif Webster, 2001
W Oct 19 Blood flukes: Schistosomiasis 249–262 (237–250)
S3
Dr. Patrick Skelly
(Schistosomiasis)
Tufts University
Pdficon small.gif Skelly, 2013
M Oct 24 Blood flukes: Schistosomiasis 249–262 (237–250)
E6 W Oct 26 Tapeworms: Cysticercosis; Taeniasis Ch 20 (both eds.); 346–351 (330–335); 355–357 (340–341)
S4
Dr. Peter Olson
(cestodes & cancer)
British Museum of Natural History
M Oct 31 Tapeworms: Echinococcosis; Diphyllobothriasis 351–355 (335–339); 341–345 (325–329)
W Nov 2 Exam II (Covers material from Oct 5th through Oct 31st)
S5
Dr. Roman Kuchta
(Diphyllobothriasis)
Czech Academy of Sciencies
M Nov 7 Nematodes: Ascariasis; Toxocarosis Ch 22 (both eds.); 433–442 (411–421)
E7 W Nov 9 Nematodes: pinworms, Hookworm disease 447–450 (425–429); 419–426 (397–405)
S6
Dr. John Hawdon
(hook worms)
George Washington University
M Nov 14 Nematodes: Filariasis; Dracunculiasis 463–474 (441–453); 479–484 (457–462)
E8 W Nov 16 Nematodes: Trichinosis; Trichuriasis 399–409 (377–388)
M Nov 21 Thanksgiving (no class)
W Nov 23 Thanksgiving (no class)
Arthropod Diseases
S7
Dr. William Campbell
(Onchocerciasis)
Merck (retired); 2016 Nobel Laureate
M Nov 28 Mites, ticks, and tick-borne diseases 639–645 (611–616); 653–655 (625–629)
E9 W Nov 30 Fleas, lice, flies and bed bugs 589–599 (563–573); 569–579 (543–554); 583–584 (557–559)
S8
Dr. Dale Clayton
(head lice)
University of Utah
M Dec 5 Human parasites and climate change
E10 W Dec 7 General considerations
Tentative date M Dec 12
6-8pm
Exam III (Covers Nov 7th through Dec 7th) & Final (Comprehensive Essays)